Prairie View lost their opener to Texas Southern 44-41 in front of 22K at Reliant Stadium. Both teams had at least 500 total yards but I doubt these teams are considered offensive powerhouses. Lamar should be able to muster enough offense to beat Prairie View if they don't make silly mistakes.
I consider this a must win game. Losing this game (or even struggling to win) would mean they are in a very long season, probably winning 3 games at the most. A big win would put them at 1-1, which is what everyone was expecting. If they struggle to win then I'll be very nervous about conference play.